Expression And Significance Of ERα, EGFR And CyclinD1 In Epithelial Ovarian Cancer

Objective To investigate the Expression of ERa、EGFR and cyclin D1in Ovarian epithelial cancer and its significance.Method Expression of ERa、EGFR and cyclin D1were evaluated by means of immunohistochemistry in primary ovarian epithelial tumors, including58malignant ones,18normal tissues, and20benign adenomas.Result1ERa、EGFR and cyclin Dl positive expression rates in Ovarian epithelial cancer were74.13%、68.97%、51.72%, respectively. Significantly higher than in normal ovarian tissue and benign ovarian tumors, the results were statistically significant differences,P<0.05.2ERa, EGFR and CyclinD1in benign ovarian tumors positive expression rate of normal ovarian tissue was no significant difference, P>0.05.3ERa, EGFR and CyclinDl positive expression rate of serous ovarian cancer(78.79%、84.85%、57.89%) and non-serous ovarian cancer (52.00%、52.00%、35.00) showed no statistical difference,P>0.05.4ERa, EGFR and CyclinD1positive expression rate in Ⅰ-Ⅱ ovarian cancer tissues were52.00%,52.00%,24.00%, significantly lower than that in Ⅲ-Ⅳ ovarian cancer (78.79%,84.85%,69.70%); The results were statistically significant differences, P<0.05. 5ERa, EGFR and CyclinD1positive expression rate in well-differentiated ovarian carcinoma were45.83%,54.17%,29.16%, significantly lower than the poorly differentiated ovarian carcinoma positive expression rate (76.47%,79.41%,58.82%) The results were statistically significant differences,P<0.05.Conclusion ERa, and CyclinD1EGFR expression in epithelial ovarian cancer than in benign ovarian tumors and normal ovarian tissue, with clinical stage and pathological grade (P<0.05), and histological type (P>0.05). ERa、EGFR and cyclin D1may play an important role in the development of Ovarian epithelial cancer.