NGAL And SLOX-1 In Patients With Atherosclerotic Cerebral Infarction And The Effects Of Atorvastatin

Objective: To investigate the effect of NGAL and sLOX-1on the formation ofcarotid atherosclerosis as well as pathogenesis of cerebral infarction by means ofstudying the expression change of NGAL and sLox-1in serum of the patients withcarotid atherosclerosis as well as the intervention effect of atorvastatin.Methods: Selecting80patients with Ischemic Stroke and carotid atherosclerosisand have received treatment in the Neurology Department of Ma Wang Dui hospitalfrom March2012to September2013, dividing them randomly into conventionaltreatment group (20mg, n=40) and intensive treatment group (40mg, n=40) andcollecting all clinical data of every patient which has been selected. Collectingpatient serum before atorvastatin treatment starts, during the treatment12weeks and24weeks Measuring the concentration of NGAL and sLox-1in patients’ serum byenzyme linked immunoabsorbent assay (ELISA). Measuring the intima-mediathickness of internal carotid and the arterial plaque area by color Doppler ultrasoundbefore treatment as well as24weeks after the treatment. Collecting experimentaldata and then doing the statistics and data analysis by applying SPSS17.0softwareand set the inspection level α=0.05Results:1.The concentration of NGAL and sLox-1is higher in serum of patientswith cerebral infarction than patients with atherosclerotic. The difference isstatistically significant (P <0.05)2The concentration of NGAL and sLox-1decreases significantlyin serum of patients after the intervention of atorvastatin. The difference isstatistically significant (P <0.05)3． Intensive treatment using atorvastatin is able to decrease theconcentration of NGAL and sLox-1more significantly compare to conventionaltreatment. The difference is statistically significant4．24weeks after the intervention of atorvastatin, the intima-mediathickness of internal carotid decreases. The difference is statistically significantConclusion:1.NGAL and sLox-1participate in the formation of carotid atherosclerosis and plaque.2Intensive treatment using atorvastatin is able to decrease NGALand sLox-1concentration effectively. It also has the function of reversingintimal thickness.