Study On The Correlation Between High - Risk Human Papillomavirus Infection And TCM Constitution

Background:According to the statistics of WHO, there is an estimated 493,000 new cases of cervical invasive cancer each year in the world,273,000 patients died of cervical cancer, which more than 4/5 were in the developing countries[1].China is a high incidence area of cervical cancer, there is an average of 132,300 new cases every year, the total incidence was 0.27%.A lot of research data shows that sustained high-risk human papillomavirus infection is an important risk factor in the high-grade cervical intraepithelial neoplasia, and the further development of cervical cancer[3-4l At present, there is no reliable effect to the treatment of traditional Chinese and Western medicine of HR-HPV, therefore, HR-HPV infection focus on the prevention. While the development of the Constitution theory of traditional Chinese medicine (TCM) provides a new idea for us to study the relationship between disease and human body, Constitution is not only a key factor in the occurrence of the disease, but also an important factor in determining the course and outcome of disease progression. Therefore, studying the patient’s constitution and related factors of HR-HPV infection is very necessary in prevention and treatment of cervical lesions and cervical cancer.Objective:Through the collection of basic data and constitution of HR-HPV infected people, I try to discuss the influence of HR-HPV infection in constitution and related factors from the Constitution theory of TCM, in the hope of providing some help in individual treatment, syndrome differentiation and prevention of HR-HPV infection.Method:This subject adopts case-control study, combined with cervical high risk HPV-DNA PCR testing results, I screened 120 patients of HR-HPV-positive as case group, then select 120 healthy women without other disease and HR-HPV-negative as control group, these people all fill in basic situation questionnaire and "the classification and determination of TCM Constitution self-test table", so as to get the basic information and the constitution classification situation of research objects, establishing Microsoft Excel database, using SPSS 17.0 statistical software for statistical analysis,and draws the conclusion.Results:1.The univariate analysis shows that HR-HPV persistent infection is associated with the level of education, work pressure, pregnancy and abortion, age of first sex, contraception, urinary tract infection, vaginitis, pelvic inflammatory disease, smoking, diet habit, family history of cancer and other factors.2. There is a significant difference between the patients of HR-HPV persistent infection and healthy women’s constitution distribution (P< 0.01), the group of HR-HPV-positive appeared the phenomenon of biased constitution aggregation, mainly in the Yang deficiency type(34.17%) and the Qi deficiency type(14.17%), healthy women in control group are mostly Peace constitution (72.5%).Conclusion:l.HR-HPV persistent infection is associated with a variety of factors, we should pay attention to health adjustment, bland diet, nutrition, forbidding to eat raw and cold foodstuffs, mixing work with adequate rest, suitable for sports, take contraceptive condoms to avoid multiple abortion or curettage, develop a healthy way of life at ordinary times.2.There is a potential association between persistent HR-HPV infection and TCM constitution type, Yang deficiency and Qi deficiency of women are more vulnerable to persistent infection of HR-HPV. Therefore, clinicians and patients should pay attention to take care of Yang Qi in the process of clinical prevention, treatment and daily nursing.