| Objective:Our study was going to investigate whether the effects of Lp(a) elevation on coronary revascularization in patient with acute coronary syndrome(ACS) were dependent on LDL-C level.Methods:Totally 326 ACS patients undergoing percutaneous coronary intervention(PCI) were recruited. All patients baseline characteristics were collected before PCI, according to the serum Lp(a) level, participants were divided into normal Lp(a) group[Lp(a) < 30mg/dl] and elevated Lp(a)group[Lp(a)<30mg/dl].Based on LDL-C level, participants were divided into LDL-C<1.8 mmol/L and LDL-C≥ 1.8 mmol/L subgroups. Followed up for Major adverse cardiovascular events(MACE) via outpatient visits or telephone call after discharging from hospital a year later.MACE including new acute myocardial infarction(AMI), shock, cardiovascular death and coronary revascularization(CR) were compared.Result:Patients in elevated Lp(a) groups more frequently presented with three vessel stenoses(34.7%,54.5%, P=0.01), no significant differences of other baseline characteristics were found between normal group and elevated group(P> 0.05). Without regard for LDL-C level, incidence of MACE and CR were higher in elevated Lp(a) group, though there was no significant differences between two groups(P > 0.05). In subgroup of LDL-C<1.8 mmol/L, no significant differences of cardiovascular outcomeswere found between normal Lp(a) group and elevated Lp(a) groups(P >0.05). While in the subgroup of LDL-C≥1.8 mmol/L, incidences of MACE and CR were significantly higher in elevated Lp(a) group than normal group(27.4%,13.4%,P=0.008;17.8%,5.8% P=0.011). No significant differenced of new acute myocardial infarction, shock, cardiovascular death were found between normal group and elevated group(P>0.05).Conclusion: With LDL-C and Lp(a) elevations, incidence of CR is significantly increased after stent implantation in patient with acute coronary syndrome.
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