Study On Synthesis And Biological Activity Of N-nitrophenyl Urea Derivatives

N-nitrophenyl urea derivatives is a kind of double-function chemical compounds. It was usually obtained by the reaction of phosgene acid chloride method. It was well known that phosgene has noxious, It is contaminative to environment and isn't easy to fix on quantity. In this subject aimed to find new secure, non-polluting synthetic method , aromatic isocyanate were synthesized by aromatic amine and triphosgene, through reaction with N-nitro-2,4,6-trichloroaniline to product aim compounds, nine novel N-nitrophenyl urea derivatives were synthesized through non-phosgene isocyanate method . The intermediates and compounds were confirmed by means of MS and IR. Their general formula is as follows:In this paper, aim to study primary herbicidal activity of compounds A, B, C, D on rape and barnyard-grass was assured with soft agar method ; Objective to explore compounds E, F, G, H, I whether exists of fungicidal activities on Rhizoctonia solani, cotton wilt pathogen, Grey mould germ of straw berry with agar dilution method. The results showed that:1 In this experiment, the isocyanate method was used, the result showed that the substitution of bis(trichloromethyl)carbonate for phosgene is safe, convenient, environment friendly, easy to fix on quantity, easy to control.2 According to the screening procedure of these new compounds, the herbicidal and fungicidal bioactivity tests were taken in the concentration of 400mg/L, 100mg/L, 10mg/L, 5mg/L, 2.5mg/L, The results showed that some of these N-nitrophenyl urea Derivatives have high fungicidal activity, compounds B, C provided excellent bioactivies...