Curative Effect Of Zinc Sulfate-Mentha Canadaensis Spray On Cow Foot Rot And Enhancing Effect Of Mentha Canadaensis On Transdermal Absorption Of Zinc

Twenty-one cows affected foot rot were divided into three groups randomly and averagely. The control group was treated through routine treatment. The other two groups were treated respectively through spraying the hoofs of cows with ZnSO₄ and zinc sulfate-Mentha canadaensis preparation which contained 10% zinc sulfate and 10% Mentha canadaensis on the basis of routine treatment. Three weeks later, only one case was cured in the control group, but three in the group treated with ZnSO₄ and five in the group treated with zinc sulfate-Mentha canadaensis liquor. The result showed the effective rate from zinc sulfate and the cure rate from zinc sulfate-Mentha canadaensis preparation were better than that from routine treatment markedly.Dividing fifty-six hoofs of normal scalpers into seven clusters, each consisted of eight. Then each group was soaked separately in normal saline, 0. 1%, 0.5%, 2.5%zinc sulfate solution, 0.5 %zinc sulfate-1% Mentha canadaensis preparation, 0.5% zinc sulfate-10% Mentha canadaensis preparation and 0. 5%zinc sulfate-100% Mentha canadaensis preparation for 6 hours. Subsequently the contents of zinc in the skin, the subcutaneous I, the II tissue of unguis, the outside layer, the central layer and the inside layer of hoof horn were measured. The results demonstrated : (1)In the control group, the zinc contents in the skin and hypoderm were respectively 25.07±3.19μg/g and 6.77±0.74～7.1 1±0.78μg/g. The significant difference existed between them. The zinc level of hoof horn was 55. 92±11.86—57.78±8.51μg/g, and there was no significant difference between layers. The zinc levels in the skin, hypoderm and hoof horn could be increased by transdermal assimilating. The zinc contents in the skin and hypoderm of unguis soaked in 0. 5%and 2. 5%zinc sulfate liquor were separately 67.21±27.27—91.64±32.45μg/g and 12.85±5.10～17.00±5.14μg/g. The zinc content in the outside layer of the hoof horn also increased to 120.90±57.87μg/g and 186.52±56.41μg/g. (3) The transdermal absorption of zinc could be improved strikingly by Mentha canadaensis preparation. The zinc contents in the skin of hoof soaked in 0.5%zinc sulfate-10% Mentha canadaensis preparation and 0.5%zinc sulfate- 100% Mentha canadaensis preparation were separately 107.39±17.36μg/g and 143.11±10.10μg/g. The zinc level in the outside layer of hoof soaked in 0.5%zinc sulfate-100% Mentha canadaensis preparation was 141.45±16.52μg/g. The results above explained the therapeutic effect of sulfate-Mentha canadaensis preparation on foot rot.