Screening On Active Ingredients In Chinese Traditional Medicines Anti Newcastle Disease Virus

Newcastle disease virus (NDV) seriously damaged to the poultry industry developing all over the world. At present, the most effective control method is vaccination for prevention.In this test, a few of antiviral Chinese traditional medicines were selected, such as Oxymatrine (Oxymatrine, OM),Glycyrrhizin (glycyrrhizic acid, GA),Chlorogenic acid (chlorogenic acid, CA), Geniposide(geniposide, GP), Polydatin (polydatin, PD), Luteolin (luteolin, LT),Rutin (RT) and Astragalu polysaccharide (Astragalus polysaccharide, APS). Screening of monomer and compound which had inhibitivity active to NDV in vitro and in vivo.The antiviral activity of four monomers and recipes showed as follow:OM>APS>GA >GP;recipe1(OM+APS)>recipe3(OM+APS+GP)>recipe2(GA+AP )>recipe4(GA+APS+GP) at former screening, and OM>APS;recipe1(OM+APS)>recipe3 (OM+APS+GP) at aga- in screening in vitro.The animal results showed that OM had significant prevention for ND,however, recipe1 had significants treatment for ND. The group of exprements showed that a higher protection ratio, less organ lesions and more remarkable enhancing in weight compared with group of virals control. It would be able to provide a therorational basis for new Chinese medicine reagents, as well as those drug for clinical prevention and treatment of NDV innovation.