Epidemiologic Survey And Treatment Of Poultry Colibacillosis In Weifang District Of Shandong Province

Chicken colibacillosis has been spread in most chicken farms in Weifang at differentdegree. More and more great economic losses brought to poultry industry. Antibiotic, whichwas used widely, has led to development of multi-drug-resistant strains, it is urgent toinvestigate and analyze the clinical cases of colibacillosis, to find the pathogeniccharacteristics and to set up more reasonable preventive and remedial measures to reducefarmer's losses and improve cultivation profit.The experiments was carried out according to the following four parts in the article.Expriment one a survey was carried on the epidemiology about Chicken colibacillosisin Weifang district of Shandong province. Investigation indicates that Chickencolibacillosis is very popular in these several years. The number of chickens infected withpathogenic Escherchia colibacilli or infected together with other pathogens add up to 35%～40% of the total ailing chicken, furthermore, the Chicken colibacillosis itself in thisdistrict is very complicated.Expriment two the drug sensitive test was done on the pathogenic Escherchiacolibacilli isolated from the chicken farms in Weifang, Shandong province. PathogenicEscherchia colibacilli was isolated from 156 chickens that exhibited typical Chickencolibacillosis pathological changes, and 102 Escherchia colibacilli strain was isolatedtotally. The sensitivity for 100 E.coli strains to twenty antibacterial drugs including:Fosfomvcin Sodium, Florfenicol, Spectinomycin and so on, was determined with drugsensitive test. Results indicated that most E.coli strains were sensitive to FosfomvcinSodium(92%), Florfenicol (81%), and Spectinomycin (84%). However, no E.coli strain wassensitive to all the drugs in the 100 E.coli strains. Nevertheless, all of the E.coli strains weremulti-drugresistence, at least, one resisted to five kinds of drug, and at most, one resisted tosixteen kinds of drugs. Expriment three protection test of drug for the chicken experimentally infected withEscherchia colibacilli. One E.coli strain (S1) was selected out from the above 100 E.colistrains, and inoculated 30-day chickening. Subsequently, chickening was treated withFosfomvcin Sodium, Florfenicol, Cefazolin, Ciprofloxacin which indicated to be effectivein the above test. The infection group and the PBS inoculated groups were set at the sametime. Results showed that the protective ratio for Fosfomvcin Sodium, Florfenicol,Cefazolin, Ciprofloxacin was 96.67%, 93.33%, 86.67% and 50.00%, respectively. It wasobviously that fewer chickening was checked to be infected with E.coli in groups treatedwith Fosfomvcin Sodium,Florfenicol and Cefazolin than in groups treated Ciprofloxacinand the infection control group. From above, it can be concluded that Fosfomvcin Sodium,Florfenicol, Cefazolin were relatively effective in pathogenic E.coli therapy to the labinfected 30-day chickening.Expriment four Fourthly, field experiments on Chicken colibacillosis. The clinicalcontrol and preventive test was put into practice in 4940 33-day chickens that exhibitedclinical symptom or non-symptom with Fosfomvcin Sodium, Florfenicol for six days inChangyi, Weifang district. Results indicated that Fosfomvcin Sodium, Florfenicol wereeffective against Chicken colibacillosis both in clinical control and disease prevention.