Preparation For Oil-Adjavent Inactive Vaccine Against Goose Parvovirus

Matierial with typical symptom of Goose parvovirus disease from goose farm in Jilin provine has been isolated and identified. Through methods of regression experiments, electricity mirror observation , ELD50 determination, young goose protection test and neutrolization test, Goose parvovirus with good security and immunogenicity has been isolated and identified . The mathod of PCR diognosis for Goose Parvovirus has been established , sequence determination and analisis of Vp3 gene in strain JLDA has been finfshed.Antigen solution was prepared from Goose parvovirus JLDA strain with good immunogenicity . The protective rate of immunized goose against GP was determined at designated time. The results show that the immune efficacy to goose is high. Goose parvovirus oil-adjavent inactive vaccine is good at security. Immunized geese are both normal in spirit and appetite. Antibody against Goose parvovirus produced fast, and protect rate from 15 days to 6 monthes was 100%, it was still 80% after 7 monthes. The period of immuno protection last 3 monthes.Goose parvovirus oil-adjavent inactive vaccine is easy to be conserved. Field tests with 6 sets of Goose parvovirus oil-adjavent inactive vaccine were carried out. The results showed that Goose parvovirus oil-adjavent inactive vaccine is safe and effective, and has no famous influence on the goose productivity. The immuno protective rate for young goose is more than 95.89%, and the survival rate of young goose was largely increased.