Study On The Relationship Between Cerebral Arterioscleriosis And Cerebral Thrombosis In Blood Stasis Syndrome

Background: Cerebral arteriosclerosis is the principal pathogenic foundation of cerebral thrombosis. Cerebral arteriosclerosis and thrombosis are closely related with endothelial cell damage, platelet activation and blood coagulation-fibriholysis system change.Aim: To discuss the relationship between cerebral arteriosclerosis and cerebral thrombosis in blood stasis syndrome, to offer objective indexes for blood stasis syndrome differentiation of TCM. 'Subjects and Methods: 60 cases ( male 36 female 24 mean age 61. 7±10. 9γ)with cerebral arteriosclerosis and 60 cases (male 42 female 18 mean age 62. 5±11. 8γ) were selected as research subjects. 34 cases with cerebral arteriosclerosis belonged to blood stasis syndrome and 26 non-blood stasis syndrome. 49 eases with cerebral thrombosis belonged to blood stasis syndrome and 11-non-blood stasis syndrome. 30 healthy people (male19 female 11 mean age 10. 8±9. 7γ) were selected as controls. The plasma levels of TM GMP-140 D-Di were detected with enzyme linked immunosorbenf assay(ELISA).Results: (l)The serum levels of TM GMP-140 D-Di of patients with cerebral arteriosclerosis were significantlyhigher than those of controls(P<0.01). Among patients, the levels of blood stasis syndrome were significantly higher than those of non-blood stasis syndrome(p<0. 05). (2)The plasma levels of TM GMP-140 D-Di of patients with cerebral thrombosis were significantly higher than those of controls (P<0. 01). Among patients, the levels of blood stasis syndrome were significantly higher than those of non-blood stasis syndrome (P<0, 05). (3) The plasma levels of TM GMP-1 D-Di of patients belonged to blood stasis syndrome with cerebral thrombosis were significantly higher than those with cerebral arteriosclerosis (P<0.01). (4)The plasma levels of TM GMP-140 D-Di of patients belonged to non-blood stasis syndrome with cerebral thrombosis were significantly higher than those with cerebral arteriosclerosis ( P < 0.05, 0. 01, 0.001).Conclusions: (1)TM GMP-140 D-Di may serve as objective indexes for blood stasis syndrome differentiation in cerebral arteriosclerosis. (2) TM GMP-140 D-Di may serve as objective indexes for blood stasis syndrome differentiation in cerebral thrombosis. (3)The elevation of serum levels of TNK GMP-140 D-Di exists both in blood stasis syndrome of cerebral arteriosclerosis and that of cerebral thrombosis and the.significant difference of amplitude- between them indicates different roles they may play in the pathogenesis of two diseases.