Effects Of Intracoronary Magnetized Stent Placement On Level Changes Of NO,ET-1,MDA,SOD And OxLDL In Coronary Sinus Of Patients With Coronary Heart Disease

Background Intracoronary Stent Placement(ICSP) has helped to lower the restenosis(RS) rate after percutaneous transluminal coronary angioplasty (PTCA) significantly, but there are still some RS rate(15/o?00/o), which gets in the way of intervention therapy. In recent years medicine and coronary arteries local treatments were developed to prevent RS. Physiotherapy stands out among the latter. Vascular irradiation, radioactive stent and intravascular low power red laser illumination have made some progresses, but they cannot be used widely due to some side effects. Magnetized stent(MS) is a new type of intracoronary stent invented by our hospital and the new type of stent can cut down RS and other coronary events after ICSP significantly, which has been proved by animal experiments and clinical trails. But its mechanism is still unknown. Nowadays Nitric Oxide(NO), Endothelin-1(ET-1) and oxidizing injury have been known to have important roles in complications after ICSP. How does MS placement affect these factors and what is the mechanism? Methods and Objectives Our study aimed to investigate the effects of .v. C magnetized stent on serum NO, plasma ET-1, malondialdehyde(MDA), superoxide dismuta.se(SOD) and oxidized low density Iipoprotein(OxLDL) in coronary sinus in patients undergoing PTCA and ICSP. All 39 patients had angiographically significant coronary artery disease, which was over 75 percent diameter stenosis of at least one epicardial artery. According to the types of stents implanted, the patients were randomly devided into two groups: non-magnetized stent(NMS) and magnetized stent(MS) groups. Blood samples were collected during the first 6 hours after PTCA and ICSP to determine the above variables. Results: I . NO level in both MS and NMS group dropped significantly immediately and rose slightly at 1 h after ICSP. There were no significant differences between two groups. At 3 h and 6 h after ICSP NO level in NMS group did not rose to pre-PTCA baseline, while that in MS ascended above the pre-level. There were significant differences between two groups(3 h P < 0.05, 6hP< 0.01). 2. ET-1 level in both MS and NMS group dropped significantly immediately after ICSP and that in NMS group dropped even more significantly. There were significant differences between two groups(P < 0.05). ET- 1 level in NMS group recovered but still below pre-PTCA baseline at 1 h, while that in MS did not changed significantly. ET-1 level continued rising to reach the pre-level in NMS group at 3 Ii, while that in MS recovered slowly. There were significant differences between two groups(P( 0.05). ET-1 level increased significantly above the pre-level in NMS group at 6 h, while that in MS only recovered to approach the pre-PTCA baseline. The differences .vI. 7 between two groups became more significant(P < 0.01). 3. MDA level in MS group was significantly lower than that in NMS at 6 h after ICSP(P < 0.01). And SOD level in MS group was significantly higher than that in NMS at 6 h(P < 0.01). At the same time OxLDL level in MS group was significantly lower than that in NMS at 6 h after ICSP(P (...