| Objective:Lipid metabolic disorder is the most important risk factor for atherosclerosis (AS). In the case of long-term hyperlipidemia, lipoproteins, especially oxidized low-density lipoprotein (oxLDL) can cause functional damage to arterial intima. New epitopes are formed in the oxidation process of Low-density lipoprotein (LDL), which can induce the body to produce specific antibody:oxidized low density lipoprotein antibody (oxLDL-Ab). Animal experiment results showed that oxLDL-Ab were positively correlated with AS lesions, while the results of clinical observations were not the same. Some studies showed that oxLDL-Ab meight play a pathogenic role in the development of AS, and others suggested that oxLDL-Ab meight play a preventive role in the development of AS lesions. Malondialdehyde (MDA) is a kind of toxic end product of lipid peroxides metabolism, and is found mainly in LDL. MDA can reflect the level of lipid peroxidation injury, while lipid peroxidation (LP) is one of the initial factors of endothelial dysfunction. The blood drop of NO is one of the hallmarks of vascular endothelial damage. Coronary atherosclerotic heart disease is one of the most common types of organ lesions caused by atherosclerosis, and also endanger human health seriously. This article aims to study the relationship between oxLDL-Ab-IgM and NO, MDA in patients with unstable angina preliminary.Methods:Totally consecutive 138 cases of hospitalized patients were collected at the Second Hospital of Tianjin Medical University during August 2008 to August 2009. All cases accepted coronary angiography.73 cases were male, with an average age (60.71±11.91); and 65 cases were female, with an average age (65.41±10.08). The objects were divided into unstable angina group of 108 cases and normal control group of 50 cases. For all selected objects, history was taken and body weight, height, and waist circumference (WC) were measured. Routine blood test, blood coagulation and renal functions were measured at the moment of admission. At the next morning of admission peripheral venous blood was taken for the measure of fasting blood glucose (FPG), blood lipids and liver functions. And another 3ml elbow vein blood was taken, and after centrifugation the upper serum was saved at the condition of-80℃for the detection of fasting insulin (FINS), oxLDL-Ab-IgM, NO, MDA. HOMA-IR was calculated with the formula HOMA-IR=FPG X FINS/22.5. SPSS 17.0 were used for statistical processing of data.Results:(1)In the unstable angina group, MDA, LDL-c, HOMA-IR, WBC were all significantly higher than that of the normal control group (p<0.05); and oxLDL-Ab-IgM, NO were significantly lower than that of the normal control group (p<0.05). (2)In the unstable angina group, correlation analysis showed that smoking, DM, HOMA-IR, MDA, LDL-c were all negatively correlated with oxLDL-Ab(p<0.05); and NO, GLO were all positively correlated with oxLDL-Ab-IgM(p<0.05). (3)In the unstable angina group, stepwise linear regression analysis showed that, NO, MDA, LDL-c, GLO are incorporated into the regression equation, the final regression equation established by oxLDL-Ab-IgM =-13.768+0.376NO-0.931MDA+1.123GLO-0.792LDL-c.The equation was evaluated by correlation coefficient (R) and determination coefficients (R). And It showed that: R=0.773, R2=0.598, it tell us that 59.8% of the change of oxLDL-Ab-IgM can be explained by the change of NO, MDA, GLO and LDL-c.Conclusion:(1) LDL may generate new epitopes in the process of oxidation, and can induce the body to produce specific antibody-LDL-Ab-IgM, and oxLDL-Ab-IgM may play an important role in the process of preventing the occurrence of atherosclerosis. (2) In patients with unstable angina, lipid peroxidation increases significantly, MDA and other metabolites of lipid peroxidation increase obviously, which leads to the dysfunction endothelial cell, and the decreased of synthesis ON. (3)There is a complex interrelationship between NO, MDA and oxLDL-Ab-IgM in patients with unstable angia pectoris, and the relationship needs further study.
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