Predictive Value Of Enhanced Inflammatory Response For Clinical Restenosis After Sucessful Coronary Stenting In Patients With Unstable Angina

Predictive Value of Enhanced Inflammatory Response for Clinical Restenosis after Sucessful Coronary Stenting in Patients with Unstable Angina Background and Aim There is growing evidence for enhanc.d inflammatory response in patients after PTCA. However, the prognostic value and the pathogenesis of the elevated reponse to coronary angioplasty in coronary atherosclerosis disease (CAD) have not been established.Therefore, we aim to investigate the association between the peak values of inflammation marker C-reactive protein(CRP) and clinical restenosis, and the relationship among the serum CRP at 48 hours post-PTCA, antibody titer of oxidized low density lipoprotein(ox-LDL) and SIL-2R one week after PTCA. Methods The prospective study was undertaken in 41 patients who underwent successful PTCA(PTCA group)for unstable angina and another 25 patients as control who underwent coronary angiography only.Levels of serum CRP and antibody to ox-LDL were measured at baseline, 48 hours and one week after PTCA respectively.CRP levels were also measured in control subjects.Al1 patients in PTCA group were followed up clinically for 6 months. An exercise testing was performed within 6 months post-PTCA and CAG was repeated in patients presented suspicious of ischemia angina. Results At six-month followed-up clinical restenosis developed in 52.6% of 19 patients with high serum CRP levels (CRP~0.3mg/dl) and in 13.6% of 22 patients with normal CRP levels(CRP