Effect Of High-dose Rosuvastin On Blood Levels Of Inflammatory Cytokines Patients With Stable Angina Undergoing Percutaneous Coronary Intervention

Objective To investigate the effect of rosvastatin on serum levels of high-sensitive c-reactive protein (hs-CRP), interleukin-18(IL-18)and lipids in patients with stable angina under-going percutaneous coronary intervention(PCI).Method Forty patients with stable angina were randomized to rosvastatin 20 mg/day for 7 days (treatment group), or to no statin treatment before PCI(control group). All patients were given conventional treatment for coronary artery disease and received rosvastatin 20 mg/day for 28 days after PCI. The serum levels of hs-CRP, IL-18 and lipids were measured at admission, before PCI and at 24 hour,28 days after PCI.Result The levels of hs-CRP and IL-18 of treatment group and control group respectively compared with that at admission:before PCI has no significance; 24h and 28d after PCI have significance. The comparisons of the synchronization levels of hs-CRP and IL-18 between treatment group and control group:at admission and before PCI have no significance; 24h after PCI has significance;28d after PCI has significance with IL-18,no significance with hs-CRP. The comparisons of the level of blood lipid of treatment group and control group:in the respective group, has significance; between the groups, has no significance.Conclusion PCI can lead to increase in serum levels of hs-CRP and IL-18; the levels of hs-CRP and IL-18 in serum could be significantly decreased in the patients with rosvastatin 20 mg/day for 7 days than to no statin treatment before PCI, thereby making it possible to reduce the occurrence of cardiovascular events.