| This study was divided into two parts. In part one, to evaluate the potential of rCBV and rCBF in preoperative assessment of histologic grading and vascularity of gliomas a correlative study of MR perfusion imaging with histologic grading and vascularity of gliomas was performed.MR imaging was performed in 32 patients by using a first-pass gadopentetate dimeglumine T2*~weighted echo-planar perfusion sequence followed by conventional imaging. The perfusion data were deconvoluted to obtain a color map of relative regional CBV(rCBV) and MTT(mean time transit). rCBV, rCBV ratio, rCBF, MTT and MTE(mean time to enhance) values were computed with a nondiffusible tracer model. The rCBV ratio of lesions was expressed as a per-centage of the relative CBV of normal white matter. The maximal rCBV ratio, rCBV, rCBF,MTT ,MTE of each lesion was correlated with the histopathologic grading of gliomas and microvessel density(MVD) obtained from samples from volumetric resection.The maximal rCBV ratio in high-grade gliomas (n 18) varied from 5.3to14.8, with a mean of 8.32?1.68 (?SD), and in the low-grade cohort (n = 14) varied from 0.89 to5.4, with a mean of 2.93?.19. The difference in relative CBV was statistically significant (P<0.001 ;Student t test).The maximal rCBV in high-grade gliomas (n = 18) varied from 43.55 to 290.54, with a mean of 152.35 ?92.86, and in the low-grade cohort (n = 14) varied from 9.66 to 168.76, with a mean of 42.99 ?45.283. This difference in rCBV was statistically significant (P<0.001; Student t test). The rCBF is higher in the patients with high-grade glioma than in those with low-grade glioma. The rCBF in high-grade cohort (n = 18) varied from 2.55 to 33.99 (13.85?0.60) and varied from 0.71 to 18.67(4.16?.88) in low-grade cohort (n14). On the basis of the Student t test, the difference is statistically significant (P |
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