The Abnormality Of Tumor Necrosis Factor And Its Soluble Receptors In Systemic Lupus Erythematosus And Its Significance

Objective To study the level of TNF-alpha and soluble receptors of TNF in systemic lupus erythematosus (SLE) patients and it抯 clinical significance. Methods Plasma level of TNF-alpha and soluble receptor I and receptor 2 of TNF (sTNFR) were determined with double antibodies sandwich ELISA in 60 SLE patients and 20 healthy controls. Other immunological index including anti ds-DNA antibody and C3 were test at same tline. SLE disease activity index (SLEDAI) and lupus activity criteria count (LACC) were recorded Plasma level of TNF-alpha and its soluble receptors between SLE patients and healthy controls, patients with and without lupus nephritis, disease active and stable were compared. Results I. Plasma level of sTNFRI and sTNFR2 were significant higher in SLE group than in control group (P