Chemical Study On Anti-hepatitis Effective Part Of Picrorhizi Compositae

Chemical ingredients of compositium are substantial bases for TCM to exert their therapeutic effects.Doing researches on chemical ingredients of compositium takes great importance in elucidating theories of TCM,indicating regularities of dispensation and mechanisms of function, optimizing preparation process, making reliable quauntitive determination and realizing the modernization of TCM for coming into the international markets.1?Viral hepatitis,liver cirrhosis, lipoidal liver, alcoholic liver and liver damages because of various reasons are common on clinical, Effective Part of Picrorhizi Compositae is made up of Rhizoma Picrorhizae and Radix Paeoniae Alba by equal~ in which many chemicle ingredients had been proved having many pharmacological actions such as hepatoprotective activity, choleretic effect, relieving ache, antivirus, anti-inflammatory.It抯 effective for patients with hepatitis.Intensifying the foundational research of compositea, illustrating secrets of compositium of TCM, combinating chemical ingredients, Pharmacology and pharmacodynamics for producting a new drug with advanced process, shortened dosage, rigid and reliable quautities standard as well as with safe, steady, effective charactors are the goals of this article.This experiment based on modern and scientific technologies has been carried out on Effective Part of Picrorhizi Compositea, Theoptimal result of extraction is refluxing three times with 70%alcohol by six times volumes and 2.5 hours for each time; The process of purification is adopting AB-8 Macropore Adsorbed Resin and collecting 3 O%alcohol eluent; Quauntity determinations of Paeoflorin and Picroside II have been finished in this anticle.2Normal and reversed phase have been used in this experiment, seven compounds have been isolated from Effective Part of Picrorhizi Compositae, using 慔-NMR, ?C-NMR, DEPT, HMQC, DQF- COSY etc., we have identificated chemical structures of five compounds: Vanillin acid HS-2, Paeoniflorin I-IS-3, Picein HS-4, Picroside I HS-5, Picroside II HS-7.The result of this article not only has important value in theory, but also provides foundation for making effective part of Picrorhizi comporsitae into a secondary new drug.