A Study On Levels Of Serum Soluble ICAM-1 In Patients With Impaired Glucose Tolerance

Objective: This study is to characterize the pattern of levels of serum soluble intercellular adhesion molecule-1 (sICAM-l)in the patients with impaired glucose tolerance and diabetic subjects, and we also examine the relationship between the levels of sICAM-1 and the body mass index (BMI), insulin resistance (HOMA-IR). fasting plasma glucose (FPG),serum total cholesterol (TC) serum triglyceride (TG) high-density lipoprotein-cholesterol (HDL-C) respectively.Material and methods: In this study, we examined the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1) in the patients (n=91) with different body mass index with impaired glucose tolerance by ELISA. We measured other datas, include BMI, HOMA-IR, FPG, TC, TG, HDL-C, in all patients. Diabetic subjects (n=30) were selected to assess the levels of sICAM-1. The control group (n=30) were examined in this study.Results: sICAM-1 levels was significantly higher in IGT patients than in nondiabetic control subjects (P<0.05). sICAM-1 levels was alsosignificantly higher in diabetic subjects than that in the control group. (P<0.05), There was no difference of the levels of sICAM-1 in the patients with IGT and that of sICAM-lin the patients with DM. There was no change of the levels of sICAM-lin the different body mass index patients with IGT. There was possitive correlation measured between the sICAM-1 levels and HOMA-IR.Conclusion: In DM patients and IGT patients, sIC AM-1 levels is increased. The levels of sICAM-1 in the IGT patients is as high as that of sIC AM-1 in the DM patients. There is a positive relationship between IR and sICAM-1 levels.