Expression Of PTEN Protein And Its Significance In Human Malignant Melanoma In The Head And Neck

Objective To investigate the expression of PTEN protein in malignant melanoma in the head and neck and its significance in clinical pathology.Method Forty-two cases of malignant melanoma in the head and neck and thirty cases junctional nevus were stained with PTEN protein rabbit antibody by SABC immu-nohistochemical method. The results were analysed with clinical pathology.Results In the PTEN-positive tumors as well as in junctional nevus, the protein was localized in the cytoplasm and in the necleus . The positive expression rate of PTEN was significantly lower in malignant melanoma than in junctional nevus(47. 62% versus 83. 33%,P