The Study Of Vascular Cell Adhesion Molecule In The Genesis Of Pregnancy Induced Hypertension

Objective To study the changes of serum VCAM-1 in PIH and its relationship in the genesis of PIH.Methods 49 women with PIH (including 15 women with mild PIH, 16 women moderate PIH, 18 women with severe PIH), 35 normal pregnant women and 30 non-pregnant women were studied. Serum levels of VCAM-1 and IL-6 were measured by Elisa. The expression of VCAM-l spiral arteries of utero-placental bed in 25 women with PIH and 20 normal pregnant women were evaluated by immunohistochemistry.Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P<0.05, P<0.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?8. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH(O) were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH. IL-6 could induce the expression of VCAM-1. The reduced expression of VCAM-1 in utero-placental bed may relate with superficial implantation. VCAM-1 may play a role in the genesis of PIH.