Study On The Expression And Correlation Of UPAR,Cathepsin D,nm23 In Gastric Cancer

Objective To study the effect of expression of urokinase-type plasminogen activator receptor (uPAR) and cathepsin D and nm23 on the infiltration and metastasis of gastric cancer and to investigate the relationship of their expression. Methods The expressions of uPAR and cathepsin D and nm23 in 59 cases of gastric cancer were investigated by immunohistochemistry, SP method, and the relation of the expressions to histologic types, infiltrating depth and lymph node metastasis was also analyzed. Results â‘ Of 59 cases of gastric cancer, 28 cases were uPAR positive and 41 cases were CD positive and 32 cases were nm23 positive. â‘¡The uPAR positive rates in papillary, tubular and mucoid adenocarcinoma were relatively higher than that in poorly differentiated carcinoma and signet-ring cell carcinoma (P<0.01), while CD and nm23 had not indicated significant difference in different histologic types (P>0.05). â‘¢uPAR positive rate in the cases with lymph node metastasis was higher than that without lymph node metastasis (P<0.01). The same result was concluded about CD (PO.05), whereas nm23 positive rate with lymph node metastsis was lower than that without lymph node metastasis(P<0.05). d)The difference of uPAR positive rate was significant among cases of early gastric cancer and cases with muscularis involvement and cases with whole layer infiltration. There was some relation between infiltrating depth of gastric cancer and CD or nm23, but no significant difference (P>0.05). (D The relationship was significant between the expression of CD and uPAR in gastric cancer(P<0.01). No relation was foundbetween the expression of CD and nm23(P>0.05) or between that of uPAR and nm23(P>0.05). Conclusion The expression of uPAR and CD were closely related to the infiltration and metastasis of gastric cancer and uPAR was related to histologic types; The simultaneous overexpression of uPAR and cathepsin D might promote the invasion and metastasis of gastric cancer. nm23 might suppress metastasis and infiltration of gastric cancer. These results suggested all the three factors might play an important role in invasion and metastasis of gastric cancer.