An Experimented Study On The Prevention Of Posterior Capsular Opacification By Using PGMS Irrigating Solution

Objective: To study the prevention of posterior capsular opacificationby using PGMS irrigating solution and the applicability in-clinical procession.Methods: Extracapsular cataract extraction was performed on rabbit eye. The experiment was divided into two groups. Infusion solutions was BSS in the control group and BSS plus PGMS in the drug group with three different concentration (0.2mg/ml, 0.4 mg/ml, 0.8 mg/ml). Clinical observation was carried out regularly by using slit-lamp microscope and ophthalmoscope. Three months later, the pathological changes of posterior lens capsular were observed by light microscopy, scanning and transmission electron microscopy. Results: There was a significant difference in posterior capsular opacification and anterior chamber reaction between PGMS-treated group and control group (P<0.05), but there was no significant difference in endothelial cell edema (P>0.05). The posterior lens capsular in the control group was covered by lens epithelial cells. There was no obvious lens epithelium multiplication and inflammatory cell attachment on the posterior lens capsular in the drug group. Conclusion: PGMS can effectively prevent the posterior capsular opacification without toxicity to adjacent ocular tissues.