The Study Of Effect Of Simvastatin On Biochemical Markers Of Bone Metabolism In Treating The Patients With Hypertipidemia

objective To investigate the effeCt of simvastatin onbiochemical markers of bone metabolism in treating the patients whhf hyperlipidenda. Methods 73 patients were selected and randomyclassified as tWo groups, trial group containing 37 patienis Whch tookthe simvastatin fOr 24 weeks (l0mg gd ) and control group consistingof 36 patients which took fenofibrate for the same time (l00mg bid ).The level of serum of blood lipidemia 1 bone sPecific alkalinephosphate (ALP )' bone gla protein (BGP ) 1 carboWednal propePtideof tyPe I procollapen (PICP )' Pyr' D-Pyr and tartrate-resistant agdphosphatase (un ) were monitored before treatmnt' 12W. 24W aftertreatment respeCtively. ResultS l. The effect of reducing lipiemia in twogroups makes no difference po0.05). 2. The amount of AlP .BGP .PICPare significantly higher at the 24W aller treatment than that beforetreatment (P<0.0l), bu the amount of Pyr \ D-Pyr. TRAP are significanlylower than before (P<0.0l). AJl the markers except blood lipidemia areno difornce in colltrOl group batWen the end of treatment andbefore that. 3 .At the end of treatment, all the markers except bloodlipidemia are draxnatically difference betWeen two groups (P<0.0l ).Conclusion The results show that simvaStatin can not only regUlatethe blood lipidemia of patients with hyperlipidemia but also promotethe formation of bone.