The Expression Of Vascular Endothelial Growth Factor And Microvessel Density In Primary Gallbladder Cancer Relating To Cancer Invasion, And Metastasis And Prognosis

Objective To study the expression of vascular endothelial growth factor and microvessel density in the progression of primary gallbladder cancer and their relationships between invasion and metastasis and prognosis.Methods VEGF and MVD in 31 cases of primary gallbladder cancer and 10 cases of chronic gallbladdercitis tissue were examined with immunohistchemical staining of S-P.Results Both the expression of VEGF and MVD in tumor-adjacent were significantly higher than those in rumor and normal tissue(P<0.01),MVD was significanty higher in VEGF positive for tumors than in VEGF negative(P<0.01),The expression of VEGF and MVD were closely correlated with the differentiation,invasion,metastasis and Nevin stage(P<0.01).The pations with VEGF positive tumors and higher MVD had a poor prognosis than those with VEGF negative tumors and lower MVD in primary gallbladder cancer. Multivariate analysis by Cox's proportional hazards model showed that the expression of VEGF is an independent prognostic factor in pations with gallbladder cancer.Conclusion VEGF and MVD are highly related to angiogenesis of primary gallbladder cancer and promotes its growth. VEGF and MVD may be regarded as one of biological indicator in primary gallbladder cancer.