Relevance Of Tumour Angiogenic Correlative Factors With Invasion, Metastasis And Prognosis Of Laryngeal Carcinoma

Objective Angiogenesis is essential for growth, development, invasion, metastasis and recurrence of malignant tumours. Endoglin (CD105), VEGF and p53 protein are involved in the process of angiogenesis, and play an important role in the aspect of diagnosis, treatment and prognosis in malignant tumours. To evaluate the clinical significance of microvessel density (MVD) and investigate the relationship of Endoglin (CD105), VEGF and p53 protein and their significance of clinical pathology, we studied the expression of Endoglin (CD105), VEGF and p53 protein in laryngeal carcinoma and compared the relevance among them in order to provide theoretic basis and experimental evidence for application of Endoglin (CD105) in the aspect of diagnosis, treatment and prognosis and research about anti-angiogenic and genic therapy in laryngeal carcinoma. Methods Pathologic paraffin-embedded sections and clinic data from 40 patients with primary squmamous cell carcinoma of larynx diagnosed and operated on at Department of Otolaryngology and Head Neck Surgery of Peking Union Medical College Hospital between 2000 and 2004 were studied. Serial sections were respectively stained for Endoglin (CD105) , CD34,...