Effect Of Temperature Of Fluid Infusion On Circulation,Respiratory Function And Some Biochemical Metabolic Values In Hemorrhagic Shock Rabbits

OBJECTIVES To investigate the effects of different temperatures of fluid infusion on circulation respiratory function and some biochemical metabolic values in hemorrhagic shock rabbits to improve our nursing care and saving ability for hemorrhagic shock patients.METHODS We used a previously described animal model of controlled hemorrhagic shock rabbits in this randomized experiment. Thirty rabbits were randomized to a warm fluid infusion ( n=8 ) , a ambient-temperature fluid infusion (n=7), a cold fluid infusion ( n=8 ) and sham-operated ( n=7 ) group. The Rabbits were then resuscitated with three times the maximal bleeding volume with Ringer' s lactate and their blood loss. Core body temperature, hemodynamic values, respiratory rate and some biochemical metabolic values were measured before shock, during shock and 1h, 2hs, 4hs after fluid infusion respectively.RESULTS1. Changes of core body temperature: Core body temperature in warm fluid infusion group kept stable at 1h, 2hs, 4hs after fluidinfusion and Core body temperature in cold fluid infusion and ambient-temperature fluid infusion group decresed. (p<0.05)2. Changes of hemodynamic values: Heart rate decreased significantly at 4hs after fluid infusion in the cold fluid infusion and ambient-temperature fluid infusion group as compared with the warm fluid infusion group. (p<0. 05) Mean arterial pressure was lower at 4hs after fluid infusion in cold fluid infusion group than other groups. (p<0. 05) There was no significant difference in CVP and shock index among groups.3. Changes of blood gas values and respiratory rate:Pa02 washigher at 1h after fluid infusions in warm fluid infusion group as compared with the cold fluid infusion and ambient-temperature fluid infusion group. (p<0. 05) PaCO2 was lower at 4hs after fluid infusions in cold fluid infusion and ambient-temperature fluid infusion group as compared with the warm fluid infusion group. (p<0. 05) There was no significant difference in arterial blood SO2 , pH and respiratory rate though arterial blood SO2 , pH and respiratory rate were recoveried earlier or kept more stable in warm fluid infusion group than that in other groups.4. Changes of some biochemical metabolic values: There was no significant difference in plasma LAC , diamine oxidase and myocardial enzyme values among groups though there was a steady downward trend in plasma LAC and there was a lower value in diamineoxidase and myocardial enzyme values from Ih to 4hs after warm fluid infusion.CONCLUSIONOur data indicate that warm fluid infusion in rabbit model of controlled hemorrhagic shock has some beneficial effect on circulation, respiratory function and some biochemical metabolic values. In view of this, we should pay more attention to the temperature of fluid infusion in nursing care for patients with hemorrhagic shock.