Early Diagonosis Of Diabetic Peripheral Neuropathy (DPN) And The Risk Factors For DPN

Objective To investigate the value of electrophysiological test for early diagnosis of diabetic peripheral neuropathy(DPN) and the risk factors related to DPN.Methods Total of 600 diabetic patients, including 63 patients with Type 1 diabetes mellitus(DM)and 537 patiens with type 2DM were investigated for DPN based on electrophysiological test including sensory or/and motor nerve conduction velocity(SNCV or/and MNCV). The related risk factors for DPN were analysed.Results The prevalence of DPN in admitted diabetic patients was 60.2%.In multivariate analysis, age, height, HbA1C and 24-h urinary albumin excretion(24 h-UAE), duration of diabetes, FBS were the main covariates for the development of DPN. Excluding markers of micro vessel and considering the reference values of Electrophysiological investigation for the anthropometric characteristics, We found the independent risk factors were HBA1c,FBS,duration of DM. The presence of DPN also correlated with presence of diabetic retinopathy(DR) and nephropathy(DN).Conclusions There is high prevalence of DPN in admitted diabetic patients. The electrophysiological test is a sensitive, objective, and targeted measure for DPN. Age, chronic hyperglycemia exposure, 24-h UAE and the duration of DM are independent risk factors for DPN, That DPN is associated with diabetic microangiopathy (DN and DR ),which suggested microangiopathy is involved in the development of DPN.