Relationship Between Central Aortic Pressure Wave And Coronary Heart Disease

Objective To study the relationship between central aortic pressure wave various data and coronary heart disease. Methods Two hundred fifty five patients were divided in non-coronary heart disease and coronary heart disease diagnosed by coronary angiography, 192 male patients, 63 female patients, mean age 56.59±10.67(32-80) years old. The two groups were matched-pair one to one by aged, sexual, diabetes, hyperlipidemia, smoke, alcohol, BMI. Pulse wave were observed in all patients. We investigate the characteristics of pulse wave in two groups. Result (1) To analysis from the aspect of time: Pulse wave transmit swifter in coronary heart disease patients than non-coronary heart disease patients. Multiple factors analysis: It was relative with coronary heart disease that transmit time (TAG) shorten from aortic to femoral. When TAG longen 20ms, the probability of CHD will decrease to 45%. (2) To analysis from the aspect of pressure: The reflected wave peak (Pc2) and systolic blood pressure (SBP) have statistics difference between coronary heart disease and non-coronary heart disease. The reflected wave peak (Pc2) and systolic blood pressure (SBP) are higher in coronary heart disease than non-coronary heart disease. Multiple factors analysis: The reflected wavepeak (Pc2) or systolic blood pressure (SBP) ascend 10mmHg, the probability of CHD will increase 1.90 or 1.82 times. (3) To analysis from the pressure difference: Various pressure difference's numerical variable data concerned with reflected wave peak (Pc2) all have statistics difference between coronary heart disease and non-coronary heart disease. When reflected wave peak (Pc2) exceed heart jets peak or amplitude formed by aortic valvule shutting decrease or disappear, the probability of CHD may increase. Multiple factors analysis: The reflected wave peak ( Pc2) and aortic valvular shutting's pressure difference ascend lOmmHg, the probability of CHD would increase 2.48 times. When reflected wave peak (Pc2) exceed heart jets peak, the probability of CHD would increase 7.67 times. When pulse pressure highten lOmmHg, the probability of CHD would increase 1.58 times. (4) To analysis from the pressure wave slope: Ascend-branch slope formed by heart jets have not statistics difference between coronary heart disease and non-coronary heart disease, but ascend-branch slope formed by reflected wave peak (Pc2) have statistics difference. Multiple factors analysis: The steeper the slope formed by reflected wave peak(Pc2) ,the higher the probability of CHD. When we recorder pressure wave in 9mmHgx40ms scale, ascend-branch angle increase 10? the probability of CHD would increase 1.5 times. Conclusion Pressure wave velocity swiften, reflected wave ahead and amplitude hoist, aortic valvule shutting wave decrease and disappear are the major characteristic of coronary heart disease patients, exist better relationship with coronary heart disease.