| PrefacePre-existing channels exist among coronary artery. When coronary artery is obstructed, the pre-existing channels may open and develop collateral circulation. Collateral circulation can provide the distal end of the obstructed blood vessels with the remaining blood and lessen the myocardial ischemia and hypoxia in the obstructed region, which has great clinical significance. However, not all the patients who have pathological changes of obstructed coronary artery are liable to form collateral circulation. The article analyzes the characteristics of pathological changes of coronary artery from 253 patients of coronary artery disease who have proved to have obstructed coronary artery by coronary angiography, and the relevant factors of the formation of collateral circulation, in order to probe into what are the determinant factors and the significant influential factors of the formation of collateral circulation of coronary artery.Subjects and Methods1. Subjects: 852 consecutive patients who have proved to have coronary artery disease by coronary angiography (at least one stenosis of coronary artery is more than or equals fifty percent) from May,1993 to September, 2002. Among them, 122 belong to Group A with the formation of collateral circulation of coronary artery. In Group A, a vast majority of the patients have the pathological changes of at least one coronary artery with complete or sub-total occlusion. Therefore, the contrasted group belongs to Group B which is made up of 133 patients who have the same pathological changes of coronary artery but without the formation of collateral circulation.2. Methods: Collect the materials of coronary angiography and clinical characteristics of the two groups. Collateral flow is graded using the classification developed by Rentrop et al: Grade 0 = no visible filling of any collateral channels; 1 = filling of side branches of the infarct artery with no dye reaching the epicardial segment; 2 = partial filling of the epicardial vessel; and 3 = complete filling of the epicardial vessel by collateral vessels. The score ranging from 2 to 3 indicates the patients have collateral circulation, while the score ranging from 0 to 1 indicates the patients don't have it. The materials of coronary angiography includes the lesion vessels, occluded vessels, occluded location, dominant coronary artery and the directions of collateral circulation, etc. Clinical materials include the patients' age, sex, history of hypertension, angina, diabetes mellitus, smoking and drinking alcohol, etc. Because we are not sure about the process of coronary artery disease of most of the patients, we can't cover them in our research. Among them, free blood glucose, triglyceride(TG), total cholesterol (TO , high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C ) from 219 patients are tested half a month before coronary angiography by complete biochemical instrument of enzyme. The abnormal critical value of TG, TC, LDL-C and HDL-C is decided according to the criteria in The Proposals ofthe Prevention and Cure of Abnormal lipidemia (TG>1.7mmol/L; TC>5.75mmol/L; LDL-C>3.6mmol/L; HDL-C<0.91mmol/L).3. Statistical methods: The quantitive data are shown by mean SD (xS) and is tested by t test. Qualitative data are tested by chi-square test. The regression analysis: the formation of collateral circulation (Y) is independent variable; age (X1), sex (X2), blood pressure (X3), blood glucose (X4), the number of the lesion vessels (X5) and the number of the occluded vessels (X6) are dependent variable, to have the multivariate stepwise logistic regression analysis. All the materials are used to conduct statistical analysis on the basis of SPSS 10.0 Software Package, and Probility<0.05 is considered significant.Results1. Among 852 patients with coronary artery disease, there are 253 ones with the occluded vessels, and the rate of occlusion is 29.69 percent. The occluded vessels reach 313.2. There are 122 patients with coronary artery disease who...
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