| Purpose: To explore and analyze: (1) the law of the change and quantitative relationships of the loss of visual acuity after closed-globe injury and PIOO wave latency and amplitudes of pattern-visual evoked potential (P-VEP); (2) the characteristics of flash-visual evoked potential (F-VEP) in patients with open-globe injury; (3) the factors affecting the visual recovery in eyes with trauma, and to provide basis of diagnosis for identifying condition of an injury, and to supply theoretic direction for prognosis evaluation of severe ocular trauma.Methods: One hundred and thirty patients with single ocular trauma were divided into two groups according to visual acuity in traumatized eyes. P-VEP examinations were conducted in 70 eyes with visual acuity better than 0.1 (group A), and F-VEP examinations in 60 eyes with visual acuity lower than 0.1 (group B). All eyes in group B were divided into two subgroups according to the standardized classification of ocular trauma: trauma in group BI was caused by a blunt object including contusion and rupture, and injury in group 62 was caused by a sharp object or foreign object(s) including intraocular foreign body injury (IOFB), penetrating, and perforating injury. All traumatized eyes were compared with the other healthy eyes.Results: (1) There was a significant prolongation in latency and reduction in amplitude of P100 wave in all eyes of group A compared with that in control group (P<0.01). (2) The visual acuity in traumatized eyes were correlated with the degrees of prolongation in latency and reductionin amplitude of P100 wave in group A (P<0.01). The extent of prolongation in latency was positively correlated with the range of reduction in amplitude of P100 wave (r=0.257, P<0.05). The age was not correlated with the visual acuity in traumatized eyes and the change of P100 wave (P>0.05). (3) The linear regression equation of visual acuity in traumatized eyes and the change in amplitude of P100 wave of P-VEP was y=0.669-0.0554x (F=36.236,P<0.01). (4) There was a significant prolongation in latency and reduction in amplitude of PIOO wave in all eyes of group B compared with that in healthy group (P<0.01). (5) The visual acuity in traumatized eyes and the final postoperative visual acuity were negatively correlated with the range of reduction in amplitude of PIOO wave in all eyes of group B (P<0.05). The visual acuity in traumatized eyes was positively correlated with the final postoperative visual acuity (rs=0.479, P<0.01). The age was not correlated with the visual acuity in traumatized eyes, final postoperative visual acuity, and the change of PIOO wave (P>0.05). The change in latency of PIOO wave was not correlated with the other indexes (P>0.05). (6) There was no significant difference in age and visual acuity in traumatized eyes between group B1 and B2 (P>0.05). The final postoperative visual acuity in group B2 was better than that in group B1 (P<0.05), and the improved degree of visual acuity in group B2 was greater than that in group B1 (P<0.05). The range of reduction of amplitude of P100 wave in group B1 was greater than that in group B2 (P<0.01). There was no significant difference in the extent of prolongation in latency of PIOO wave between the two groups (P>0.05). (7) All eyes in group B were disabled by injury (best corrected visual acuity, BCVA, <0.3), 31 eyes were blind in groupBI (BCVA<0.05), and 26 eyes were blind in group B2. The visual acuity was improved in 26 eyes in group B1 by operation, in which 20 eyes were improved more than one level, 17 eyes were out of blindness, 11 eyes were out of disable, and 6 eyes were stable. The visual acuity was improved in 27 eyes in group B2 by operation, in which 26 eyes were improved more than one level, 23 eyes were out of blindness, 12 eyes were out of disable, and 1 eye was stable. The effective rate was 92.86% and the rate of vision better than 0.05 was 88.46% postoperatively in group B2, and were significantly higher than that in group B1 which were 62.50% and 54.84% respectively (P<0.01). Th...
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