Serial Changes And Significance Of Serum Interleukin-10 In Patients With Cerebral Thrombosis

Objective To study the effect in the consequence of the brain damage, by observing the serial changes of serum interleukin-10 (IL-10) in patients with cerebral thrombosis.Methods 30 patients with cerebral thrombosis as observed group. Patients' serum was serially measured at three times; within 24 hours (as soon as the patients were examined) , at day 3, at day 7. Infarct volume was determined, too. Peripheral leukocytes were simultaneously counted within 24 hours. Twenty age-matched healthy subjects were tested as the control. Serum level of IL-10 was measured with available quantitative "sandwich" enzyme-linked immunosorbent assay.Results The serum level of IL-10 in observed group was significantly higher than that in control group (P<0. 01). The level of IL-10 was markedly elevated at day 1, which peaked at day 3 and tended to decrease thereafter. However, its level remained significantly elevated compared with that of control group even at day 7. The level in larger diameter of infarct was higher than that in smaller (P<0. 05). The level of peripheral leukocytes was markedly higher than that in control group (P<0. 05).Conclusions The expression of the anti-inflammatory cytokine, IL-10, was induced in the consequence of the cerebral thrombosis, which could provide neuroprotection. These indicate that IL-10 plays an important role in the processes of neuron functional recovery and survival after ischemic brain damage. The change of serum IL-10 was associated with the region and course of cerebral ischemia. The fact that using IL-10 can provide therapy to cerebral infarction and decrease damage in ischemic stroke, which is an encouragement to pursue in the future.