The Separation And Determination Of Main Chemical Components Of Saururus And Research Of Its Effects And Pharmacodynamic Medicine On Diabetes

Diabetes is one of the three most serious illnesses that greatly affect human's health in modern society. Many efforts have been made on the research of medicines that can control and cure this illness. Kinds of classical medicines can be found from the history materials resulting from the abundant experience of diabetes therapy using Traditional Chinese Medicine(TCM). Recent year's aim of treating diabetes by TCM has been turned to the selection of single-medicine to have a better effect. Saururs is a kind of single-medicine which was found recently having a good effect on reducing the blood-glucose, but no paper about its functional chemical components has been reported. This research focuses on Saururus' functional chemical components of reducing the blood-glucose and studies the mechanism medicine behind its function to provide data for further study and clinical practice, and makes the foundation for the new drug exploitation. In this research includes:1. Establish Alloxan type diabetes model to investigate the best experimental conditions of such model. 2. Measure the continually change of Superoxide dismutase(SOD), methane dicarboxylic(MDA) and Blood Glucose level by multi-feeding of Saururas decoction to judge the effect of therapy on alloxan type diabetes rats. 3. Measure the change of SOD, MDA and Blood Glucose level by feeding alloxan type diabetes rats with different components extracted from Saururus to find the effectual chemical components.With successful modeling of alloxan type diabetes, we see a significant decrease in SOD level while MDA level increases, which hints a more serious damage to cell. Saururus decoction takes into effect on reducing the blood Glucose after 3 hours of feeding and such effect can last for more than 8 hours. It helps to lift the anti-oxidation ability of SOD and reduce the MDA lipid's oxidation. After treating with the total flavone, total amino acid and polysaccharide extracted from Saururus, the increase of serum SOD and the decrase of MDA level in the alloxan-induced rabbits were observed.This research shows, Total flavone , total aminophenol and polysaccharide extracted from saururus can decrease blood-glucose(GLU), cholestero, increase SOD and decrease MDA, adjust the level of insulin. Saururus and its effectual components can be used for prevention and cure of tetrpyrimidinetype diabetes. Its effect on improving complication of diabetes is better than that of western medicine.