The Clinical Study Of Guchong Zhixue Decoction In Treating Hemorrhagic Period Of Dysfunctional Uterine Bleeding With Qi Deficiency And Blood Stasis Syndrome

Objective: To explore systematically the effect and the hemostasis principle of Guchong Zhixue Decoction (GCZXD) in treating dysfunctional uterine bleeding (DUB) with Qi deficiency and Blood stasis syndrome based on the theoretical and clinical research under the guidance of traditional and western medical theory. Method: 60 patients were divided randomly into test group (30 cases, treated with GCZXD) and control group (30 cases, treated with Yigong Zhixue Mixtures). The hemostasis effect, the improvements of clinical symptoms and the density of endometrium, prothrombrn time (PT) and activated partial prothrombrn time (APTT), the serum level of Ca2+, serum sex hormone, the concentrations of PGE2 and PGF2α, the levels of endometrial ER and PR were observed. Results: GCZXD could improve clinical symptoms of patients obviously, and the difference was significant compared to control group. Meanwhile, the density of endometrium and PT, APTT were decreased, the serum level of Ca2+ was increased compared to that of the pretherapy, and the difference was significant compared to control group. It showed that the efficiency of test group is significantly superior to that of control group in adjusting PGE2/PGF2α and ER/PR. Conclusion: GCZXD is an effective recipe in treating DUB with Qi deficiency and Blood stasis syndrome. The effect may be achieved through the operation of promoting cruor, improving the serum level of Ca2+, adjusting the concentrations of PGE2, PGF2α and the levels of endometrial ER, PR.