Associated Study Between Hypertension And A1166/C Polymorphism Of Angiotensin Ⅱ Type 1 Receptor Gene

Objective Angiotensin II type 1 receptor (AT1R) is one of the important factors in the process of blood pressure regulation, as well as in the damage of target organs. The mutations of ATIR gene lead to the changes of ATIR function. The current study was conduct to analyze the distribution characters of single nucleotide polymorphisms 1166A/C of AT1R gene (SNP), and to investigate the association between AT1R gene SNP and essential hypertension and hypertensive left ventricular remodeling in Chinese Southern Hans. The research was expected to provide the basis of identification of predisposing genes and prevention and cure for essential hypertension.Methods A case-control study of 148 cases and 164 controls was carried out with molecular epidemiological study and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The AT1R genotype and gene frequencies were analyzed, and further hierarchical analyses were conducted according age and serum total cholesterol (TC). Independent fatalness of AT1R genotypes and alleles toward hypertension and hypertensive left ventricular remodeling were analyzed by Logistic regression.Results All the 3 genotypes in site 1166 of ATI R gene were identified among 312 individuals. The 1166C allele frequency of AT1R gene was 0.111 in cases and 0.055 in controls (P<0.05); in all subjects with hypercholesterolemia when serum TC level was hierarchically analyzed, the 1166C allele frequency in two groups was 0.144 and 0.046 respectively (PO.01); in youth of cases and controls, the frequency was 0.182 and 0.054 respectively (P<0.01). Hypertensives with AC/CC genotypes had more increased LVMI than those with AA genotype when covariant factors were rejected (127.23 : 116.08, P<0.05). The 1166C allele was related with hypertension and hypertensive left ventricular remodeling when analyzed by Logistic regression, the OR is 1.998 (95%CI: 1.073-3.851) and2.482 (95%CI: 1.203-9.796) respectively.Conclusion 1166A/C SNP is associated with hypertension development. 1166C is susceptible allele and 1166AC/CC are susceptible genotypes. Further more, 1166C alleleis concerned with the development of premature essential hypertension and can increase the fatalness of suffering from hypertension in subjects with hypercholesterolemia. And 1166C is susceptible allele for the development of hypertensive left ventricular remodeling.