The Treatment Of Peripheral Vascular Thrombosis By Intraluminal Ultrasound Thrombolysis In Dogs

Objective In order to evaluate the therapeutic effect of intraluminal ultrasound thrombolysis (UT) in treatment of peripheral vascular thrombosis, we established model of peripheral vascular thrombosis and observed the changes of vascular endothelium and venous valve after UT. Method 15 dogs were divided into three teams at random, with 5 dogs in each. The proximal and distant ends of the femoral arteries and veins in both posterior limbs of the dogs were ligated respectively to establish model of femoral arterial and venous thrombosis. The femoral arteries and veins in one limbs were selected randomly to accept UT, the other side accepted no special treatment. Dogs were treated at 1, 4, 7 day after the ligation. The formation ofthe thrombi and the recanalization of the femoral arteries and veins were observed and recorded. After UT, the arteries and veins were excised and the pathologic changes in vascular endothelium and venous valve were examined. Result The thrombi were found in all the 30 arteries and 30 veins at 1, 4, 7 day after the ligation. The recanalization in femoral arteries of the UT team was 14/15 in 24-126 s. The recanalization in femoral veins of the UT team was 13/15 in 32-152 s. By comparison with the control team, there was no significant difference in vascular endothelium or venous valve injury in the UT team.Conclusion The method of establishing model of peripheral vascular thrombosis by the ligation of the proximal and distant ends of the femoral blood vessel is simple and shows satisfied effect; UT shows satisfied short -term effect in treatment of peripheral vascular thrombosis, but more attention should be given to the long-term effect.