| Objective To investigate the significative indicator for monitoring treatment and evaluating curative effect of herbal therapy with effect of dispelling the moisture and activating blood circulation combining with thrombolytic therapy with urokinase for treating lower extremity deep venous thrombosis(DVT).Methods Gold colloids immunofiltration assay (GIA) was used to detect D-dimer in the plasma in 26 patients with DVT at different time during the traditional Chinese medicine therapy combining with thrombolytic treatment using urokinase (before treatment, 1 day, 3 days, 1 week, 2 weeks after the beginning of the treatment and 1 day after the end ). At the same time, the perimeter of both lower limbs was measured above 15cm and below 10cm of the knee to compare the difference between the suffered limb and the healthy one.Statistic Method Using the software of SPSS 11.0.Results In this series, the effect was cure in 21 patients, effective in 4 patients, noneffective in 1 patient. The total effective rate was 96.2%. D-dimer levels increased significantly after thrombolytic treatment, peak value appeard at 2nd day. At 1 week they decreased to the levels before treatment, and there was very significant difference at 2 weeks comparing with the levels before thrombolysis. D-dimer decreased to normal levels when the treatment concluded. The change of the D-dimer levels was accorded with the drop of the perimeter difference of both lower limbs.Conclusion Herbal therapy with effect of dispelling the moisture and activating blood circulation combining with thrombolytic therapy is markedly effective in the treatment of DVT, especially in chronic DVT . D-dimer seems to be a significative indicator for monitoring treatment and evaluating curative effect of thrombolysis for treating DVT. |
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