The Study Of Effects Of Alcohol On Kindled Models

Alcohol is a primary chemical substance which is proned to be applied mistakenly or excessively in society. There are many reports about the inhibitory effect of alcohol on central nervous system (CNS). However, the antiepileptic effect of alcohol on animal chronic kindling model has not been reported.Objective: To investigate the antiepileptic effect of alcohol on lidocaine kindling and amygdala kindling models in rats and combine alcohol with phenobarbital or diazepam to observe the effect on their antiepileptic actions.Methods: To produce the amygdala kindling model and lidocaine-induced kindling model and observe the effects and mechanism of alcohol on the development of kindling and kindling seizure activity, the effects of alcohol on general antiepileptic drugs are also observed by combination-administration.Results: Alcohol, at doses of 0.5-1.Sg-kg^ip, can decrease the Racine's stages (P<0.05), increase the focal afterdischarge threshold, reduce the Racine's stages and the percentage of generalized seizure, inhibit the development of kindling(P<0.01) and the seizure activity (P > 0.05); All at ineffective doses on kindling, the combination of alcohol (0.5g.kg~l) with phenobarbital or diazepam, shows no significant effect on ADD and Racine's stages (P>0.05); Alcohol (0.75.1 .5g-kg-1 ip) can significantly inhibit the rate of seizure and death in MES experiment (P<0.01) . Conclusion: The above results suggest that alcohol can inhibit seizure activity of lidocaine-kindling and amygdala-kindling, but at ineffective doses on kindling, alcohol has no synergism with phenobarbital or diazepam.Yang Bo (pharmacology) Directed by Yue Wang...