Study Of Myocardiol Damage In Patients With Type 2 Diabetes Mellitus By Applying Ultrasonic Integrated Backscatter

Objective To evaluate the diagnostic value of ultrasonic integratedbackscatter (IBS) technique in detecting myocardial damage in patients with type 2 Diabetes Mellitus .Methods Seventeen type 2 Diabetes Mellitus patients without noncardiacdiabetic complications, seventeen type 2 Diabetes Mellitus patients with noncardiac diabetic complications and sixteen normal subjects were studied by Hewlett Packard SONOS echocardiographic system with AD-IBS. The time averaged value of IB(IBS),the calibrated time-averaged value of IB(IBS% ) , the magnitude of the cyclic variation of IB(CVIB),and the transmural gradient of IBS%(TGIB) were detected. The area of interest for backscatter measurements was placed in the septum wall and in the left ventricular posterior wall(parasternal long-axis view ).Glycosylated hemoglobin (HbAlc) was measured in the patients with type 2 Diabetes Mellitus .Intergroup differences were tested for significance by means of Student's t tests.The correlation between TGffi and HbAlc was analyzed.Resu Its 1 .The IBS% of the septum and left ventricular posterior wall wassignificantly higher in diabetic patients than in the control group(P<0.05).2.The CVIB of the septum and left ventricular posterior wall was significantly lower in diabetic patients than in the control group(P<0.05).3.The TGIB values increased significantly in the patients group (P<0.01).4. Integrated backscatter parameters of patients with noncardiac diabetic complications had significant difference from those of patients without noncardiac diabetic complications (P<0.05) .5.Indiabetic patients ,there was a significant correlation between glycosylated hemoglobin (HbAlc) and TGIB(r=0.481,0.642,P<0.01,P<0.001).Conlusions Ultrasonic integrated backscatter parameters are helpful inassessing myocardial damage sensitively and determining of the degrees of myocardium injury of type 2 Diabetes Mellitus patients.