A Study On The Expression Of HSP70 And HSP90 In Human Non-small Cell Lung Cancer

Lung cancer is by far the most frequent cause of death from cancer in the world. The oncogenesis, development and prognosis of lung cancer are the incident in a way of multiple courses, which is controlled by a lot of lung cancer-related genes. It has been proved that the HSP70 and HSP90 were closely related to the oncogenesis, development, tumor immune, multiple drug resistance and prognosis of the cancer patients. In this study, the expression of HSP70 and HSP90 was detected in 124 patients with lung cancer and 30 patients with benign pulmonary lesion as control by immunohistochemistry.The results showed that: (1) The expression of HSP70 and HSP90 in lung cancer tissues was significantly higher than that in paracancerous tissues and benign pulmonary lesion tissues (P<0.01), but no significant difference was observed between the paracancerous tissues and benign pulmonary lesion tissues (P>0.05). (2) The expression of HSP70 and HSP90 in lymph nodes with cancer involvement was remarkably higher than that in those without cancer involvement (P<0.05). (3) The expression levels of HSP70 and HSP90 in cancer tissues was closely related to the P-TNM stages of the cancer, and lymph node invasion, but not to the histological classification, cell differentiation of the cancer, size of the primary tumor, location of the cancer, and age, sex of the patients and smoking or not (P>0.05). (4) The expression of HSP70 and HSP90 in lung cancer tissues was closely correlated with the postoperative survival rate in NSCLC. The five-year survival rate in patients with high expression of HSP70 and HSP90 was remarkably lower than that in patients with low HSP70 and HSP90 expression (P<0.01).Conclusions: (1) Overexpression of HSP70 and HSP90 existedin lung cancer tissues. (2) The expression of HSP70 and HSP90 in lung cancer tissues was closely related to the P-TNM staging and status of lymph node invasion of the cancer. (3) Detection of HSP70 and HSP90 in lung cancer tissues might be helpful to predict the prognosis and guide the postoperative multimodality therapy of the patients with lung cancer.