The Effects Of Zhuhuang Granule No.Ⅱ On T Lymghocyte Subsets And SIL-2R And Sympotoms Of Active Psoriasis Vulgaris Patients With Depression

Objective: Zhuhuang Granule No.Ⅱ has the effects of Qing Re Jie Du, Yi Qi Yang Yin,Shu Gan Jie Yu. This study is to investigate the therapeutic effect on active psoriasis vulgaris with depression of Zhuhuang Granule No.Ⅱ and its effective mechanism.Methods: 64 cases who were active psoriasis vulgaris patients with the indexes≥0.5 based on Zung self-rating depression scal(SDS) were divided into trial group and control group. The cases of trial group were treated by Zhuhuang Granule NO.Ⅱ and the cases of control group were treated by Qingdai pill. The T lymphocyte subsets(CD3, CD4, CD8) in peripheral blood and the sIL-2R in serum of all cases in trial group and control group were examined before treating and after treating. All cases in both groups were evaluated by SDS and Psoriasis Area Severity lndex(PASI) before treating and after treating.Results: 1. The PASI of All cases in both of the trial group and controlgroup decreased after treating, but the improvement in Zhuhuang Granule No.Ⅱ group was more remarkable than that in Qingdai pill group(P<0.01). 2. The index of SDS of all cases in both of the groups declined after treating, bat the drop of the Zhuhuang Granule No.Ⅱ group was more remarkable than that in Qingdai pill group(P<0.01). 3. The levels of CD3, CD4, CD8 and the ratio of CD4/CD8 in both groups were all improved, but the improvement of those in Zhuhuang Granule NO.Ⅱ group was more notable than that in Qingdai pill group(P<0.05 or P<0.01). 4. The levels of sIL-2R in both groups were all doun-regulated, but the declining of that in Zhuhuang Granule NO Ⅱ were lower than that in Qingdai pill(P<0.01). Conclusions: Zhuhuang Granule NO.Ⅱ can markedly lessen the lesion and improve the depressed emotion of the active psoriasis vulgaris patients with depression. It also has significant effect on the regulation of abnomal immune function in those patients.