～(99m)Tc-MIBI Combined With CT And Serum Tumor Markers Detect Pulmonary Nodules And Monitor Chemotheraputic And Radiotherapeutic Response Of Lung Cancer By ～(99m)Tc-MIBI

Object:To discuss that 99mTc-MIBI combined with CT and serum tumor markers to detect pulmonary nodules and monitor chemotheraputic and radiotherapeutic response of lung cancer by 99mTc-MIBI.Methods:50 patients who X-ray indicated suspected nodules underwent 99mTc-MIBI, X-CT and the detection of serum tumor markers (includeCEA, NSE, CYFRA211, measured with chromatometry chemoluminescenceN ELISA and RIA), calcuate the sensitivity, specificity and accuracy respectively, then combined three methods to detect the pulmonary nodules, calcuate sensitivity, specificity and accuracy again, to determine the clinical value of combined three methods.Rusult:1.compared with 99mTc-MIBI,combined detection with three methods increased sensitivity and accuracy (P<0.05), but specificity had no significant statistically difference.2. compared with X-CT, combined detection increased specificity (P<0.05), but sensitivity and accuracy had no significant statistically difference.3. compared with serum tumor markers, combined detection not only increased sensitivity, specificity (P<0.05), but also accuracy (P<0.05) .4.If the patients with lung cancer underwent 99mTc-MIBI before chemotherapy, we found that the higher the T/N is,the better chemotheraputic response is obtained.5. If the patients with lung cancer underwent 99mTc-MIBI before and after chemotherapy, we found that the more T/N percentage decreased, the better chemotheraputic response is obtained.Conclusion:1.99mTc-MIBK X-CT, serum tumor markers, three methods were combined to detect benign and malignant pulmonary nodules is better than that only use one method.2.99mTc-MIBI is a useful method for monitoring the chemotheraputic response of lung cancer.