| Objective: Atherosclerosis is an inflammatory disease related with the dysfunction of endothelium. The dysfunction of endothelium is a preceding factor of atherosclerosis. A plenty of risk factors in cardiovascular disease can result in endothelial dysfunction, while endothelial dysfunction appears with cardiovascular disease and accelerates the cardiovascular disease. C reactive protein (CRP) is a non-special marker of overall inflammatory response. It has been proved that hs-CRP (hypersensitive CRP) is an independent predictive factor which can predict disease happening in both healthy human and patients with acute coronary syndrome.It is necessary to moderate endothelial function and anti-inflammatory reaction to the risk factors. It has been proved that atorvastatin can decrease blood cholesterol, moderate endothelial function, inhibit smooth muscle cell (SMC) proliferation and mobilization, inhibit thrombosis, inflammatory response and make the vulnerable plaque stable. The aim of the study is to discuss the effect of atorvastatin on the function of endothelium and hs-CRP in healthy adults.Subjects: 15 healthy doctors and nurses, 7 cases were male and 8 cases were female among them, mean age 33.8±4.3 year-old. All of the subjects had not used contraceptive and glucocorticoid drugs and drunk.Methods: All of the subjects were treated by atorvastatin orally at 20mg daily in the morning. The flow-mediated endothelial dependent relaxation of brachial artery was measured by Doppler ultrasound before and after 1d, 3d, 1week treatment respectively. Simutaneously they fasted for 12 hours. The triglyceridel (TG), total cholesterol (TC) were measured by chemistry methods. NO was measured by chromatometry methods. ET-1was measured by enzyme-linked immunosorbentassay (ELISA).Results:1. TC was reduced after 1 day's therapy (p<0.05). After 3 days and 1 week TC were reduced obviously (p<0.01).2. After one day's treatment of atorvastatin, NO was increased, ET-1 was reduced (p<0.05). After one week the difference was more obvious (p<0.01).3.1 After one day's treatment of atorvastatin,basical flow volume of brachial artery, flow volume of reactive hyperemia and nitroglycerin sublingual administration were increased (p<0.05). After one week they were increased more significant (p<0.01).3.2 After 1 day, basical brachial artery diameter and diameter of reactive hyperemia were increased (p<0.05). After 3 days, brachial artery diameter of nitroglycerin sublingual administration was increased. After one week they were significantly increased (p<0.01).3.3 After one week, the percentage of the brachial artery diameter change of reactive hyperemia was increased (P<0.05). The percentage of the brachial artery diameter change of nitroglycerin sublingual administration was not increased.4. The percentage of the brachial artery diameter change of reactive hyperemia was not related to TC level.5. Endothelium dependent vasoldilation was positively correlated to NO and oppositely correlated to ET-16. Hs-CRP decrease was not related to TC level.Conclusions:1. Lipid lowing was observed after one day's treatment of atorvastatin.2. NO increase and ET-1, CRP decrease were observed after one day's treatment of atorvastatin.3. The vascular endothelial function can be improved after one week's therapy.4. The improvement of vascular endothelial function and lowing CRP were lipid-independent statin effects, they were related to NO increase and ET-1 decrease.5. Hs-CRP decrease induced by atorvastatin was not correlated to thelevel of cholesterol. |
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