The Prevalence And Predictors Of Atherosclerotic Renal Artery Stenosis--126 Patients Undergoing Cardiac Catheterization

Objective: Prevalence of atherosclerotic renal artery stenosis (ARAS) were studied in Patients with coronary artery disease or suspected coronary by angiography, then the degree and location of renal artery stenosis(RAS) were screened, and risk factors of ARAS were identify as early.Methods: 129 patients were studied from October 2002 and Novenber 2003. Patients' data and blood samples were collected before cardiac catherization and renal artery angioplasty were performed. Coronary artery angiography and renal arteriography performed by Seldinger and Judkins technique. Independent variables included hypertesion, smoking ,congestive heart failure , diabetes mellitus, age, peripheral vascular disease, serum creatinine, blood cholesterin and glycerin, and dependent variable was RAS. The significant variables in the univariate model were then analyzed in multivariate logistic regression model to identify the best set of independent predictors of RAS.Statistical significance was defined as P<0.05.Results: 126 patients' mean age were 63.18 +9.53(82 males,44 females).24(19.04%) had ARAS, 13(10.32%) had significant RAS (,50%), Significant unilateral stenosis was 15.87% and bilateral stenosis was 3.17% of the total patients.The ostial lesions was 60.7% ,the main stem was 35.7% and the branch was 3.57% of 28 renal artery stenosis.By univariate and multivariate logistic regression analysis, predictors included smoking(OR=1.26,P=0.044), coronary artery disease(OR=1.91,P=0.003), hyperlipidemia (OR=1.96,P=0.001), triple coronary artery diseases (OR=1.13,P=0.048).Conclusion: (1) The prevalence of atherosclerotic renal artery stenosis is 19.04% in a patient population undergoing cardiac catheterization, RAS is more commom in the ostial sites. (2) Risk factors of ARAS existencing are smoking , coronary artery disease , peripheral vascular disease , hyperlipidemia , renal insufficience, and independent predictors are smoking , coronary artery disease and hyperlipidemia.(3) There issignificant correlation between triple vessel diseases of CAD and the presence of ARAS.