1.Research Of Effection Of Resveratrol On Inhibiting Growth Of Colon Cancer Cell SW480 2.Effect Of Resveratrol On Expression Of β-Catenin,Cyclind1 In Colon Cancer Cell SW480

Objectives: To investigate the effect of resveratrol on inhibiting growth in human colon cancer SW480,and to study the anti-cancer mechanism of resveratrol.Methods: SW480 cells were treated with resveratrol at various concentration.MTT assay was used to examine growth and proliferation after treatment with resveratrol.Flow cytometry(FCM) was used to analyse cell cycle distribution.The ultrastructural changes of cancer cells were observed with transmission electron microscope.Results: Resveratrol significantly ihibited growth and proliferation of SW480 cells in time and dose dependent manner.Resveratrol perturbed cell cycle,and arrested SW480 cells in S-phase accompanied with reducing G2-phase cells.The ultrastructural change of the SW480 cells treated with resveratrol were as following:the number of microvilli on the surface ofplasm membrance decreased and the nucleolar margination was frequent in nucleus.Conclusion: Resveratrol may inhibit SW480 cell growth and proliferation by perturbing cell cycle and inducing apoptosis.