Clinical Research Of Xiangshapingweisan On Curative Effect In Patient With Dyskinesia-Like Functional Dyspepsia

1. To observe the effect of Chinese herb xiangshapingweisan (XSPWS) on gastrointestinal motility in patient with dyskinesia - like functional dyspepsia (FD) which includes gastric emptying and velocity of small intestinal transit of the standard meal, the ameliorative degree of the symptoms and the electrogastric variety before and after taking medicine.2. To develop a new kind of gastrointestinal prokinetic Chinese herb.Methods37 patients with FD selected from digestive medical outpatient service of the second affiliated hospital of China Medical University were enrolled into the study. The diagnostic standard matched to Rome II's. They hadn' t other diseases of digestive system such as gastroduodenal erosion, ulcer, tumor, moderate and hypergastritis by endoscopy and physicochemical examination. Patients whose gastric emptying time exceeded control group by + 2 standard deviation could be included. At the same time, 15 health volunteers had no dyspeptic symptoms were enrolled in as control group. Each patients with dyskinesia - like FD ingested a capsule containing 20 radiopaque markers together with standard meal and plain abdominal films were made after 5h and 72h respectively. The emptying time of standard meal of stomach and small intestines was compared before and after taking medicine. At the same time electrogastrography ( EGG) was taken to compare the electrogastric rhythm before and after taking medicine. Then inquired each symptom and evaluated the curative effect of the medicine by counting the variety of the cent of the symptom before and after taking medicine. Mental state of the patients enrolled into the study were evaluated by HospitalAnxiety and Depression Scale (HAD).ResultsThe percentage of normal preprandial [ ( 38. 41 ± 22. 69) % vs (28. 67 ± 20.79) % ] and postprandial [ (49. 24 ± 14. 95 ) % vs (32. 71 ± 17. 80) % ] eleclrogaslric rhythm in most of ihe patients with dyskinesia - like FD increased after XSPWS was taken. Preprandial [(56. 66 ± 22. 68)% vs (63. 20 ± 21.53)%] and postprandial[ (47. 00 ± 17. 21)% vs(64. 24 ± 17. 19)% ] rate of bradygastria decreased after XSPWS was taken. Preprandial [ ( 85. 47 ± 34.49) % vs ( 87. 33 ± 29. 80) % ] and postprandial [ (65. 60 ± 17. 35 ) % vs (87. 13 ±28.41)%] dominant frequency instability coefficient (DFIC) decreased after XSPWS was taken. Difference as indicated above was notable after meal(P <0. 05). The exhaustion rate of barium strips in patients[5h; (15. 88 ± 20. 36) % ;72h: (74. 51 ±45. 57) ] obviously declined as compared with the normal human [ 5h: (94. 00 ± 8. 06) % ;72h: (92. 00 ± 9. 78) % , P < 0. 01 ]. Gastric exhaustion rate( exhaustion rate of barium strips of 5h)in patients obviously increased[ (60. 23 ± 20. 84) % vs ( 25. 00 ± 12. 34) % , P < 0. 05 ] while small intestinal exhaustion rate (exhaustion rate of barium strips of 72h) had no obvious increase[ ( 84. 09 ± 18. 10) % vs ( 80. 68 ± 14. 08) % , P > 0. 05 ] after XSPWS was taken. Each of the patients' subjective symptom obviously improved after XSPWS was taken(P <0. 05). 11 patients had symptoms of anxiety while 9 had depression. The incidence was 29.73% and 48.65% respectively. 9 patients had both of the two symptoms whose incidence was 24. 32%.Conclusions1. XSPWS can increase regulation and stability of EGG in patients with dyskinesia - like FD. It can also improve the function of gastric motility.2. XSPWS can promote gastric motility to the patients with dyskinesia - like: FD. It has no obvious effect on motor function of small intestines.3. XSPWS can obviously improve the patients' subjective symptom withdyskinesia - like FD.4. Incidence of anxiety and depression was higher in patients with dyskinesia - like FD.5. XSPWS is a kind of safe and efifective gastric prokinetic Chinese herb.