The Study Of Relation Between The Infection Of Chlamydia Pneumoniae And Acute Myocardial Infarction

The established independent risk factors for atherosclerosis ( AS) and corre-lating diseases, especially coronary artery disease (CAD) include dyslipidemia, hypertension, diabetes , smoking, gender, age and family history have been widespread admitted in the practice of prevention and cure to CAD. However, they do not completely explain the pathogenesis of the diseases and people have to search for additional risk factors for diseases. More and more data suggest that the potential role of infection develop atherosclerosis and the injury of vassal dissepiment is one of main cause of atherosclerosis. Chlamydia pneumoniae ( CP) is one of the hot spot in the studies. But there are some opposite conclusions and interpretations in the studies and investigators have not gained accepted conclusions in the mechanisms of the association between infection with CP and AS.ObjectiveThe present study measured 30 acute myocardial infarction ( AMI) patients and 30 controls specific CP IgG, IgM antibody and triglycerides ( TG) , total cholesterol(TC) , low - density lipoprotein cholesterol ( LDL - C) , high - density lipoprotein cholesterol (HDL-C) , fasting blood glucose (FBG) to evaluate the association between prior infection with CP and AMI, the mechanisms of this association as well as.MethodsTwo groups of patients were investigated between Feb, 2003 and Mar ,2004 at clinic and emergency in hospital. The AMI group consisted of 30 people admitted because of an acute myocardial infarction and the control group were 30 people without known coronary artery disease. A micro - immunofluorescent as-say(MIF) was used to measure specific CP IgG, IgM antibody. Meanwhile the serum lipids and FBG were performed in the laboratory of hospital.Result1. There were 43 men(71.67%) and 17 women(28. 33% ) in all cases, mean age 58.42 10.96, range 38-83. The generally clinical data, including age, gender, smoking, body mass index(BMI) , and prevalence rate of hyper-tension and diabetes, were no difference occurred in the two groups (p >0. 05). Compare with control group, the levels of TG, TC and LDL- C in AMI group were significantly higher( p <0.05). HDL - C was lower than in AMI group, but there was no statistical significance (p >0.05). Apart from the serum lipid, the generally clinical data of two groups were comparability.2. The number of checking out specific CP IgG antibody from different levels of < 1:16, 1:16, 1:64, 1:256 and 1:512 separately were 7(23. 3% ) , 8 (26.7% ) , 10(33.4% ) , 4( 13. 3% ) , 1(3. 3% ) . After the samples were indicated specific CP IgM antibody positivity, we assayed them rheunuitoid factor (RF) using latex agglutination test and all the results were negativity. According to the standard of diagnosis, the CP prior infection rate of AMI group was higher than that of control group (73.33% Vs 33. 33% , p <0. 05). 1 patient was diagnosed as CP acute infection in AMI group, while no one in control group. The difference was no statistical significance (p >0.05).3. All the cases were divided into positive group of CP prior infection and negative group of CP prior infection. The levels of TG,TC and LDL - C in positive group were significantly higher than negative group( p <0. 05). In positive group HDL - C was lower and FBG was higher than in negative group ;but the differences were no statistical significance (p >0.05).Conclusion1. The CP prior infection rate of AMI group was significandy higher; so CP prior infection maybe one of the risk factors of AS.2. The levels of dyslipidemia in positive patients of CP prior infection were significandy higher; so the mechanisms of the association between CP prior infection and AS maybe dyslipidemia.