Changes Of Plasma Lipoprotein Concentrations After An Oral Glucose Load And Their Relation To Insulin Resistance In Type 2 Diabetic Patients

To observe the changes of plasma lipoprotein concentrations after an oral glucose tolerance test and research their relation to insulin resistance in Type 2 diabetic patients.MethodsThe age, duration of diabetes, sex, waist circumference, hip circumference, waist-hip ratio, height, body weight, body mass index (BMI), systolic blood pressure, diastolic blood pressure, fasting plasma glucose, HbAic, fasting insulin, and fasting and 60-, 120-, 180 -minute post-load plasma glucose, plasma insulin, triglycerides (TG ) , high-density lipoprotein cholesterol (HDL-C) , low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TO after a 75-g oral glucose tolerance test were measured in 26 Type 2 diabetic patients. Comparison of plasma fasting lipoprotein concentrations and post-load lipoprotein concentrations was made, and the relation between fasting and post-load lipoprotein concentrations and Homa-IR was researched. Stepwise multiple regression analysis was applied to investigate the areas under the lipoproteins' curves over 180 minutes.ResultsThe declination of post-load lipoprotein concentrations after the 75-g glucose tolerance test was statistically significant (P<0.01) . Plasma TG concentrations both in fasting and post-load state were positively related to Homa-IR (P<0.05) , and plasma HDL-C concentrations in fasting andpost-load state were negatively related to Homa-IR (P<0.05 ) . However, the correlation between both fasting and post-load state LDL-C and TC concentration and Homa-IR had no statistical significance. Moreover, stepwise mutiple regression analysis revealed Homa-IR was the independent factor capable of modulating the area of HDL-C curve over 180 minutes after the 75-g glucose tolerance test (P<0.05) .Conclusion1. There is a significant declination of plasma lipoproteins after a 75-g glucose tolerance test.2. Plasma fasting and post-load TG and HDL-C concentrations are related to insulin resistance.3. Insulin resistance plays a significant role in the post-load HDL-C concentration after 75-g oral glucose tolerance test.