Study On The Relationship Of Vasoactive Peptides Such As Adrenomedullin And The Change After Therapy In Essential Hypertension

Objective To study the relationship between the risk stratification in hypertension and the levels of plasma VWF, ADM and ET-1,and explore the clinic significance.Methods 80 essential hypertensives were randomly recruited and divided into 4 groups: the low risk group (n=20), the medium risk group(n=20), the high risk group(n=19),the very high risk group (n=21), 20 healthy persons recruited as the control group. The levels of plasma ADM,ET-1 were determined by radioimmunoassay, and VWF by ELISA Results The levels of plasma VWF increased significantly in low risk group compared to that of the control group (t=2.57, P<0.05), and those of ET-1, ADM were very significantly increased (t=4.12; 6.46 P<0.01). The levels of plasma ET-1, ADM, VWF in medium risk group , high risk group and very high risk group were increased very significantly than those in the control group (t=4.412-25.306, P<0.01). In EH subjects, there were significant differences in ET-1, ADM and VWF. There were positive correlations among the levels of plasma ADM and ET-1, VWF ( =0.602,0.683; P<0.01). There were difference of the plasma ET-1, ADM and VWF before and after treatment (t=3.71~20.8, P<0.01). Conclusions (1) ADM,ET-1 and VWF were involved in thepathophysiology of essential hypertension. (2) The levels of plasma ET-1,ADM and VWF could reflect the risk stratification in essential hypertension.(3) The effective therapy after control blood pressure and risk factor could reduced the plasma levels of ET-1,ADM,VWF and improved Endothecial Function.