Study On The Relationship Of Vasoactive Peptodes Such As Adrenomedullin To The Risk Stratification In Essential Hypertension

Objective To study the relationship between the risk stratification in hypertension and the levels of plasma ADM,ET-1,CGRP and ANP.Methods 80 essential hypertensives were randomly recruited and divided into 4 groupsrthe low risk group,the medium risk group,the high risk group,the very high risk group,20 healthy persons recruited as the control group.The levels of plasma ADM,ET-1,CGRP and ANP were determined by radioimmunoassay. Results The levels of plasma ADM,ET-1,ANP increased significantly in EH subjects compared to those in the control group (t=5.824~28.945,P<0.01).The levels of plasma CGRP decreased significantly compared to those in the control group(t=4.139~12.668,PO.01).In EH subjects,there were no significant differences in the levels of plasma ADM,CGRP,ET-1 and ANP between the low risk group and the medium risk group(t=0.299-1.883,P>0.05).There were significant differences in the levels of plasma ADM,ET-1,ANP and CGRP among the low risk group and the high risk group,the very high risk group (t=4.032~15.649,P<0.01).There were significant differences in the levels of plasma ADM,ET-1,ANP and CGRP among the medium risk group and the high risk group,the very high risk group.(t=2.818-15.993,P<0.01).There were significant differences in the levels of plasma ADM,ET-1 and CGRP between the high risk group and the very high risk group (t=3.324-6.510,P<0.01).There were no significant difference in the levels of plasma ANP between the high risk group and the very high risk group(t=0.869,P>0.05).There were positive correlations among the levels of plasma ADM and ET-l,ANP(r=0.850;0.708,P<0.01).There were negative correlationsbetween the levels of plasma ADM and CGRP(r=0.742,P<0.01).There were positive correlations between the levels of plasma ET-1 and ANP(r=0.712,P<0.01).There were negative correlations between the levels of plasma ET-1 and CGRP(r=0.687,P<0.01).Conclusions ADM,ET-1,CGRP and ANP serving as vasoactive peptides involved in the pathophysiology of essential hypertension.The levels of plasma ADM,CGRP,ANP and ET-1 could reflect the risk stratification in essential hypertension ,and could be as a marker for risk stratification.