Clinical Epidemiological Analysis In 625 Kidney Disease Patients Underwent Renal Biopsy

Objective: To investigate the demographic feature, distributional profile of histopathological types, transitional trend in constitution of specific diseases, and interrelationship between pathological and clinical pattern in patients underwent renal biopsies. Method: From January 1997 to October 2002, histological diagnosis of renal disease was made in 625 patients aged 10~68 in 1st affiliated hospital of Anhui Medical university (Hefei, China). Demographic data were obtained from all patients. Results: The mean age of the whole group patients was 28.24+9.68 years, 53.9%patients were male. A high incidence rate (72.3%)of this group patients occurred at the age from 20 to 39 years. Glomerular disease accounted for 94.1%of the total renal patients biopsied. Except mesangial proliferative lesion (MsP), IgA nephropathy (IgAN) was the most frequent pathologic classification (19.9%) of (PGD). The lupus nephritis was the most frequent in secondary glomerulonephritis(77.1%). Along the 6 years, an increment of prevalence was found in focal segmental glomerulosclerosis (FSGS) (p=0.0000) and a decrement in membranous nephropathy (MN) (P=0.0000) over 1997-1999 as compared with those during 2000-2002. In 625 patients, durition of FSGS was the longest, and endocapillary proliferative glomerulonephritis (EnPGN) was the shortest. In total renal patients biopsied, nephritic syndrome (NS) was the most frequent clinical manifestation (33.6%). In IgAN, the most frequent clinical manifestations was macrographic haematuria(54.8%); while MN, MCD, MPGN were frequently showed as NS; FSGS, MsP, MCD and MPGN frequently as Uab; In primary glomerular disease, MN was the most frequent classification in those showed as NS, EnPGN frequently as ANS, MsP Uab, IgAN frequently as iGH and rGH. The pathological classifications related withrenal failure were various. In the cases for the positive reaction of HBsAg(17.9%), more incidence rate occurred at MN as compred with the cases for the negative reaction of HBsAg . Conclusion: Male- adolescent were predominent in this group of patients,in the primary renal diseases, more IgAN, in secondaey renal disease, more LN. Along the 6 years, an increment of percentage was found in FSGS. Nephrotic syndrome was the most frequent clinical manifestation. It is verified that the similar pathological change may manifest various clinical profile, vice versa; nevertheless, these is a internal relation each other. In the cases for the positive reaction of HBsAg more incidence rate occurred at MN as compred with the cases for the negative reaction of HBsAg.